Description

Perampanel CAS NO 380919-67-5 is a high-purity, non-competitive antagonist of the AMPA-type glutamate receptor. This compound is of critical importance in advanced pharmaceutical research and development, specifically targeting neurological pathways. It is primarily required by pharmaceutical manufacturers, research institutions, and contract development organizations engaged in the development of novel treatments for epilepsy and other central nervous system disorders.

Application

• Active Pharmaceutical Ingredient (API) in the formulation of antiepileptic drugs.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.
• Biochemical Research for studying AMPA receptor function and excitatory neurotransmission.
• Preclinical Development for investigating new therapeutic applications in neurology and psychiatry.
• Process Chemistry for the development and optimization of synthetic routes.

Basic Information

Item	Detail
Product Name	Perampanel
CAS No.	380919-67-5
Molecular Formula	C23H15FN2O3
Molecular Weight	386.37 g/mol
Synonyms	Fycompa; E2007; 2-(2-Oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile; (3S)-2-(2-Oxo-1-phenyl-5-(pyridin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile; AMPA receptor antagonist; Perampanel hydrate; Perampanel monohydrate
EINECS	Contact for details

Quality Control

Our Perampanel is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent determination, to ensure it meets stringent pharmaceutical-grade specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0%; Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.