Description

Perampanel is a highly selective, non-competitive antagonist of the AMPA-type glutamate receptor. This targeted mechanism of action makes it a critical active pharmaceutical ingredient (API) for the development of advanced neurological therapeutics. It is primarily utilized by pharmaceutical manufacturers and research institutions in the global life sciences sector for the formulation of anti-epileptic drugs and in cutting-edge neurological research.

Application

• Pharmaceutical API: Core active ingredient in the manufacture of prescription medications for the adjunctive treatment of partial-onset seizures and primary generalized tonic-clonic seizures.
• Neurological Research: A vital tool in preclinical and clinical research for studying AMPA receptor function, excitatory neurotransmission, and related neurological pathways.
• Drug Development: Serves as a reference standard and key intermediate in the R&D pipelines for novel central nervous system (CNS) targeting compounds.
• Formulation Development: Used in the development of various dosage forms, including tablets and other oral formulations, requiring high-purity active components.
• Analytical Standard: Employed as a certified reference material in quality control laboratories for HPLC, LC-MS, and other analytical method development and validation.

Basic Information

Product Name	Perampanel
CAS No.	380919-34-6
Molecular Formula	C23H15N3O
Molecular Weight	349.39 g/mol
Synonyms	2-(2-Oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile; Fycompa; E2007; AMPA receptor antagonist; Perampanel hydrate; Perampanel monohydrate; (3S)-2-(2-Oxo-1-phenyl-5-(pyridin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile
EINECS	Contact for details

Quality Control

Our Perampanel is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed-upon standards for pharmaceutical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.