Description

Perampanel is a highly selective, non-competitive antagonist of the AMPA-type glutamate receptor. This targeted mechanism of action makes it a critical active pharmaceutical ingredient (API) for the development of advanced neurological therapeutics. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on addressing specific central nervous system disorders, ensuring the production of high-purity, efficacious medications.

Application

• Pharmaceutical API: Primary use as the active ingredient in the formulation of antiepileptic drugs (AEDs) for adjunctive treatment of partial-onset seizures.
• Neurological Research: Serves as a key reference standard and investigational compound in preclinical and clinical studies targeting glutamate-mediated excitotoxicity.
• Drug Development: Used in the R&D of new therapeutic entities for conditions where AMPA receptor modulation is indicated.
• Analytical Standard: Employed as a high-purity standard in quality control laboratories for HPLC, LC-MS, and other analytical method development and validation.
• Generic Pharmaceutical Manufacturing: Essential for companies producing generic versions of approved perampanel-based medications for global markets.

Basic Information

Product Name	Perampanel
CAS No.	380918-54-7
Molecular Formula	C23H15N3O
Molecular Weight	349.38 g/mol
Synonyms	2-(2-Oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile; Fycompa; E 2007; Perampanelum; AMPA receptor antagonist; (3S)-2-(2-Oxo-1-phenyl-5-(pyridin-2-yl)-1,2-dihydro-3H-pyridin-3-yl)benzonitrile
EINECS	Contact for details

Quality Control

Our Perampanel is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed-upon standards for pharmaceutical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.