Description

Perampanel CAS NO 380918-53-6 is a potent and selective non-competitive antagonist of the AMPA-type glutamate receptor. This targeted mechanism of action makes it a critical active pharmaceutical ingredient (API) for the development of advanced neurological therapeutics. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on treating refractory partial-onset seizures and other central nervous system disorders.

Application

• Pharmaceutical API: Core active ingredient in the formulation of antiepileptic drugs (AEDs) for the treatment of partial-onset seizures with or without secondary generalization.
• Neurological Research: A vital tool compound in preclinical and clinical research for studying AMPA receptor function, excitotoxicity, and novel pathways for CNS drug discovery.
• Drug Development: Serves as a reference standard and a key starting material for the synthesis and development of next-generation neurological and psychiatric medications.
• Generic Pharmaceutical Manufacturing: Essential for companies producing generic versions of approved perampanel-based medications, ensuring therapeutic equivalence.
• Clinical Trial Material (CTM): Supplied under GMP conditions for use in Phase I-III clinical trials investigating new indications or formulations.
• Analytical Testing: Used as a high-purity reference standard in quality control (QC) and analytical laboratories for HPLC, LC-MS, and other spectroscopic methods.

Basic Information

Product Name	Perampanel
CAS No.	380918-53-6
Molecular Formula	C23H15N3O
Molecular Weight	349.39 g/mol
Synonyms	2-(2-Oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile; Fycompa; E2007; AMPA receptor antagonist; Perampanelum; Perampanelo; (3S)-2-(2-Oxo-1-phenyl-5-(pyridin-2-yl)-1,2-dihydro-3H-pyridin-3-yl)benzonitrile
EINECS	Contact for details

Quality Control

Our Perampanel is manufactured and controlled under a strict quality management system. We provide material suitable for pharmaceutical development, with specifications meeting or exceeding common industry standards for API intermediates and reference materials. Certificates of Analysis (COA) are provided with each batch, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC, GC, and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.