Description

(E)-2-(3-(4-Methoxyphenyl)Acrylamido)-n-((Tetrahydrofuran-2-Yl)Methyl)-4,5,6,7-Tetrahydrobenzo[B]Thiophene-3-Carboxamide is a high-purity, advanced pharmaceutical intermediate featuring a complex molecular architecture designed for targeted activity. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel therapeutic agents with potential applications in challenging disease areas. Pharmaceutical R&D laboratories and fine chemical manufacturers need this precise intermediate for developing new drug candidates, particularly in oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel small-molecule drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its unique tetrahydrobenzo[b]thiophene and acrylamido scaffold.
• Oncology Drug Discovery: Serves as a core structure for developing potential kinase inhibitors or other targeted cancer therapies.
• CNS-Active Compound Synthesis: Employed in the synthesis of molecules designed to cross the blood-brain barrier for neurological applications.
• Custom Synthesis & Contract Manufacturing: A critical component for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke APIs for clinical trials.
• Biochemical Tool Compound: May be used in vitro as a probe to study specific biological pathways and protein interactions.

Basic Information

Product Name	(E)-2-(3-(4-Methoxyphenyl)Acrylamido)-n-((Tetrahydrofuran-2-Yl)Methyl)-4,5,6,7-Tetrahydrobenzo[B]Thiophene-3-Carboxamide
CAS No.	380890-54-0
Molecular Formula	C25H30N2O4S
Molecular Weight	454.59 g/mol
Synonyms	(E)-2-[[(2E)-3-(4-Methoxyphenyl)prop-2-enoyl]amino]-N-[(oxolan-2-yl)methyl]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide; 2-[(E)-3-(4-Methoxyphenyl)acrylamido]-N-[(tetrahydrofuran-2-yl)methyl]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide; 4,5,6,7-Tetrahydro-N-[(tetrahydro-2-furanyl)methyl]-2-[[3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]amino]benzo[b]thiophene-3-carboxamide; 380890-54-0; BDBM50164957; AKOS025310193; FT-0775789; EN300-114881
EINECS	Contact for details

Quality Control

Our (E)-2-(3-(4-Methoxyphenyl)Acrylamido)-n-((Tetrahydrofuran-2-Yl)Methyl)-4,5,6,7-Tetrahydrobenzo[B]Thiophene-3-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened under inert atmosphere conditions for optimal long-term stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.