Description

6-Carboxyl-4-Phenyl-3,4-Dihydrocoumarin Cinchonidine is a high-purity, advanced pharmaceutical intermediate derived from the cinchona alkaloid family. This compound is valued for its role as a key chiral building block in the synthesis of complex organic molecules, particularly in the development of active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and manufacturers in the pharmaceutical and fine chemical industries for applications in asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized as a chiral auxiliary or ligand in catalytic asymmetric reactions to induce stereoselectivity.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies and the development of new therapeutic agents.
• Fine Chemical Production: Used in the manufacture of specialty chemicals requiring high enantiomeric purity.
• Catalyst Development: Investigated for use in developing new organocatalysts for green chemistry applications.
• Academic & Industrial R&D: A valuable reagent for exploratory synthesis in both academic laboratories and industrial R&D departments.

Basic Information

Product Name	6-Carboxyl-4-Phenyl-3,4-Dihydrocoumarin Cinchonidine
CAS No.	380636-40-8
Molecular Formula	C₂₆H₂₅NO₅
Molecular Weight	431.48 g/mol
Synonyms	6-Carboxy-4-phenyl-3,4-dihydro-2H-1-benzopyran-2-one cinchonidine salt; Cinchonidine 6-carboxy-4-phenyl-3,4-dihydrocoumarin; 4-Phenyl-6-carboxy-3,4-dihydrocoumarin cinchonidine; (8α,9R)-Cinchonan-9-ol 6-carboxy-4-phenyl-3,4-dihydro-2H-1-benzopyran-2-one; Cinchonidine salt of 6-carboxyl-4-phenyl-3,4-dihydrocoumarin
EINECS	Contact for details

Quality Control

Our 6-Carboxyl-4-Phenyl-3,4-Dihydrocoumarin Cinchonidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for assay and chiral purity, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.