Description

3-[4-(2,3-Dihydro-Indole-1-Sulfonyl)-Phenyl]-Acrylic Acid is a specialized organic building block featuring a unique molecular scaffold combining indoline, sulfonyl, and acrylic acid functionalities. This compound is of significant interest in advanced pharmaceutical research and development, particularly as a key intermediate for synthesizing novel small molecule therapeutics. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new active compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of potential drug candidates, especially those targeting enzymes or receptors where the indoline-sulfonyl-phenyl-acrylate motif is pharmacologically relevant.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and combinatorial chemistry libraries to explore new chemical space for drug discovery programs.
• Bioconjugation & Probe Development: The acrylic acid moiety can be utilized for conjugation reactions, making it suitable for creating fluorescent probes or affinity labels for biological target identification.
• Agrochemical Synthesis: Acts as an intermediate in the research and development of new crop protection agents and pesticides.
• Material Science Precursor: Potential use in the synthesis of specialized monomers for advanced polymeric materials with specific optical or electronic properties.

Basic Information

Product Name	3-[4-(2,3-Dihydro-Indole-1-Sulfonyl)-Phenyl]-Acrylic Acid
CAS No.	379729-42-7
Molecular Formula	C17H15NO4S
Molecular Weight	329.37 g/mol
Synonyms	1-[(4-(2-Carboxyethenyl)phenyl)sulfonyl]-2,3-dihydro-1H-indole; 3-[4-(2,3-Dihydro-1H-indol-1-ylsulfonyl)phenyl]-2-propenoic acid; 3-[4-(Indoline-1-sulfonyl)phenyl]acrylic acid; (E)-3-[4-(2,3-Dihydroindole-1-sulfonyl)phenyl]acrylic acid; 1-[(4-(2-Carboxyvinyl)phenyl)sulfonyl]indoline; 3-(4-(Indolin-1-ylsulfonyl)phenyl)acrylic acid
EINECS	Contact for details

Quality Control

Our 3-[4-(2,3-Dihydro-Indole-1-Sulfonyl)-Phenyl]-Acrylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.