Description

6-tert-Butyl-2-(2-Chloro-Acetylamino)-4,5,6,7-Tetrahydro-Benzo[B]Thiophene-3-Carboxylic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant commercial importance as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities and proprietary drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug molecules, especially those targeting central nervous system (CNS) disorders or inflammatory pathways.
• Organic Synthesis Building Block: Used in research and development for constructing novel benzo[b]thiophene derivatives, a privileged structure in medicinal chemistry.
• Agrochemical Research: Potential application as an intermediate in the development of new generation herbicides or fungicides, leveraging its specific heterocyclic core.
• Material Science Precursor: Can be utilized in the synthesis of specialized organic compounds for advanced materials research.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis projects and scale-up activities under cGMP conditions.

Basic Information

Product Name	6-tert-Butyl-2-(2-Chloro-Acetylamino)-4,5,6,7-Tetrahydro-Benzo[B]Thiophene-3-Carboxylic Acid Methyl Ester
CAS No.	379256-23-2
Molecular Formula	C17H24ClNO3S
Molecular Weight	357.90 g/mol
Synonyms	Methyl 6-tert-butyl-2-[(2-chloroacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate; 6-tert-Butyl-2-(2-chloroacetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid methyl ester; 379256-23-2; 6-(tert-Butyl)-2-[(2-chloroacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid methyl ester; Methyl 6-(1,1-dimethylethyl)-2-[(2-chloroacetyl)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
EINECS	Contact for details

Quality Control

Our 6-tert-Butyl-2-(2-Chloro-Acetylamino)-4,5,6,7-Tetrahydro-Benzo[B]Thiophene-3-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.