Description

Ethyl 2-Amino-4-(3,4,5-Trimethylphenyl)Thiophene-3-Carboxylate is a high-purity, functionalized thiophene derivative serving as a critical building block in advanced organic synthesis. Its molecular architecture, featuring a multi-substituted phenyl ring and an ester-protected amino group, makes it an invaluable intermediate for constructing complex heterocyclic systems. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiophene core.
• Material Science: Serves as a monomer or building block for creating conjugated polymers and organic semiconductors used in OLEDs, solar cells, and sensors.
• Chemical Synthesis: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) and cyclization reactions to construct more complex polyheterocyclic frameworks.
• Dye & Pigment Industry: Acts as an intermediate for synthesizing specialized dyes and pigments due to its chromophoric thiophene structure.

Basic Information

Product Name	Ethyl 2-Amino-4-(3,4,5-Trimethylphenyl)Thiophene-3-Carboxylate
CAS No.	379250-77-8
Molecular Formula	C16H19NO2S
Molecular Weight	289.39 g/mol
Synonyms	2-Amino-4-(3,4,5-trimethylphenyl)thiophene-3-carboxylic acid ethyl ester; Ethyl 2-amino-4-mesitylthiophene-3-carboxylate; 4-(3,4,5-Trimethylphenyl)-2-aminothiophene-3-carboxylic acid ethyl ester; 2-Amino-4-(3,4,5-trimethylphenyl)-3-thiophenecarboxylic acid ethyl ester; ATTC Ethyl Ester; CAS 379250-77-8
EINECS	Contact for details

Quality Control

Our Ethyl 2-Amino-4-(3,4,5-Trimethylphenyl)Thiophene-3-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the stringent requirements for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.