Description

(2-[(4-Chlorophenyl)Sulfonyl]-1,2,3,4-Tetrahydroisoquinolin-1-Yl)Acetic Acid is a high-purity, advanced pharmaceutical intermediate of significant interest in modern organic synthesis. This compound matters for its role as a key building block in the development of novel active pharmaceutical ingredients (APIs), particularly those targeting complex biological pathways. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material for synthesizing potential therapeutic agents, where its specific molecular architecture enables precise chemical modifications.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Chemical Synthesis Building Block: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization processes.
• Research & Development: Essential for academic and industrial R&D focused on developing new heterocyclic compounds with biological activity.
• Process Chemistry: Employed in scale-up and route development for the production of complex organic molecules under GMP or non-GMP conditions.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Product Name	(2-[(4-Chlorophenyl)Sulfonyl]-1,2,3,4-Tetrahydroisoquinolin-1-Yl)Acetic Acid
CAS No.	378227-98-6
Molecular Formula	C17H16ClNO4S
Molecular Weight	365.83 g/mol
Synonyms	1,2,3,4-Tetrahydro-2-[(4-chlorophenyl)sulfonyl]isoquinoline-1-acetic acid; 2-[(4-Chlorophenyl)sulfonyl]-1,2,3,4-tetrahydro-1-isoquinolineacetic Acid; 2-(4-Chlorobenzenesulfonyl)-1,2,3,4-tetrahydroisoquinoline-1-acetic acid; (2-((4-Chlorophenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acetic acid; 378227-98-6; 1-Isoquinolineacetic acid, 1,2,3,4-tetrahydro-2-[(4-chlorophenyl)sulfonyl]-
EINECS	Contact for details

Quality Control

Our (2-[(4-Chlorophenyl)Sulfonyl]-1,2,3,4-Tetrahydroisoquinolin-1-Yl)Acetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS). We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing purity, related substances, and residual solvents to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider storage under an inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.