Description

4-(3,5-Dioxo-4-Azatricyclo[5.2.1.0(2,6)]Dec-8-En-4-Yl)Butanoic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its complex, rigid bicyclic lactam structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, where its specific stereochemistry and functional groups are essential for achieving desired biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, especially for neurological targets.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new pharmacophores.
• Process Chemistry Development: Serves as a standardized starting material for scaling up API synthesis under current Good Manufacturing Practices (cGMP).
• Asymmetric Synthesis: Utilized in chiral synthesis due to the embedded stereogenic centers within its tricyclic framework.
• Bioconjugation & Probe Development: The carboxylic acid moiety allows for derivatization and conjugation, useful in creating biochemical probes.

Basic Information

Product Name	4-(3,5-Dioxo-4-Azatricyclo[5.2.1.0(2,6)]Dec-8-En-4-Yl)Butanoic Acid
CAS No.	377767-35-6
Molecular Formula	C₁₃H₁₅NO₄
Molecular Weight	249.26 g/mol
Synonyms	4-(3,5-Dioxo-4-azatricyclo[5.2.1.0²,⁶]dec-8-en-4-yl)butanoic acid; 4-(3,5-Dioxo-4-azatricyclo[5.2.1.0²,⁶]dec-8-en-4-yl)butyric acid; Butanoic acid, 4-(3,5-dioxo-4-azatricyclo[5.2.1.0²,⁶]dec-8-en-4-yl)-; 4-Azatricyclo[5.2.1.0²,⁶]dec-8-ene-3,5-dione, 4-(3-carboxypropyl)-; CAS 377767-35-6
EINECS	Contact for details

Quality Control

Our production of 4-(3,5-Dioxo-4-Azatricyclo[5.2.1.0(2,6)]Dec-8-En-4-Yl)Butanoic Acid adheres to stringent quality protocols suitable for pharmaceutical R&D and pre-clinical manufacturing. Each batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and consistency. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.