Description

Phosphonium, [(3'R)-1'-[(1,1-Dimethylethoxy)Carbonyl]-2-Oxo[1,3'-Bipyrrolidin]-3-Yl]Triphenyl-, Bromide is a high-purity, chiral phosphonium salt used as a key intermediate and catalyst in advanced organic synthesis. This compound matters for its role in facilitating asymmetric transformations, enabling the production of enantiomerically pure molecules critical for modern pharmaceuticals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for chiral drugs.
• Asymmetric Catalysis: Employed as a chiral phase-transfer catalyst or ligand precursor in enantioselective alkylation and other C-C bond-forming reactions.
• Peptidomimetic Synthesis: Used in the construction of complex pyrrolidine-based structures that mimic peptides for drug discovery.
• Agrochemical Research: Serves as an intermediate in developing novel, chiral crop protection agents with improved efficacy and environmental profiles.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and process chemistry optimization.
• Fine Chemical Production: Used in the custom synthesis of specialty chemicals requiring high stereochemical purity.

Basic Information

Item	Details
Product Name	Phosphonium, [(3'R)-1'-[(1,1-Dimethylethoxy)Carbonyl]-2-Oxo[1,3'-Bipyrrolidin]-3-Yl]Triphenyl-, Bromide
CAS No.	376653-42-8
Molecular Formula	C₃₃H₄₀BrN₂O₃P
Molecular Weight	623.56 g/mol
Synonyms	(R)-1-((tert-Butoxycarbonyl)-2-oxo-1,3'-bipyrrolidin-3-yl)triphenylphosphonium bromide; (3'R)-1'-(tert-Butoxycarbonyl)-2-oxo-1,3'-bipyrrolidin-3-yl-triphenylphosphonium bromide; Chiral Bipyrrolidinone Phosphonium Salt; Boc-Protected Chiral Phosphonium Salt; Asymmetric Synthesis Reagent; PTC Catalyst Intermediate; CAS 376653-42-8
EINECS	Contact for details

Quality Control

Our Phosphonium, [(3'R)-1'-[(1,1-Dimethylethoxy)Carbonyl]-2-Oxo[1,3'-Bipyrrolidin]-3-Yl]Triphenyl-, Bromide is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for chiral purity and assay, NMR for structural confirmation, and KF titration for water content, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.