Description

5-Chloro-4-Fluoroindole is a high-value halogenated indole derivative, serving as a critical building block in advanced organic synthesis. Its unique molecular structure, featuring both chloro and fluoro substituents, makes it an essential intermediate for creating complex molecules with tailored biological and physical properties. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in kinase inhibitor and receptor modulator programs.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and plant growth regulators that require specific halogen patterns for efficacy.
• Material Science Research: Acts as a precursor for organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Chemical Biology Probes: Employed in the synthesis of fluorescent tags and molecular probes for studying biological processes.
• Academic & Contract Research: Serves as a versatile starting material for methodological studies in organic chemistry and custom synthesis projects.

Basic Information

Product Name	5-Chloro-4-Fluoroindole
CAS No.	376646-56-9
Molecular Formula	C8H5ClFN
Molecular Weight	169.58 g/mol
Synonyms	4-Fluoro-5-chloroindole; 5-Chloro-4-fluoro-1H-indole; 1H-Indole, 5-chloro-4-fluoro-; 376646-56-9; 5-Chloro-4-fluoro-indole; 4-Fluoro-5-chloro-1H-indole
EINECS	Contact for details

Quality Control

Our 5-Chloro-4-Fluoroindole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.