Description

n-Acetyl-D-Mannosamine-D3 is a deuterated derivative of N-acetyl-D-mannosamine, a key biochemical precursor. This compound is specifically valued for its use as a stable isotope-labeled internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy in analytical research. It is essential for scientists and manufacturers in the pharmaceutical, biotechnology, and advanced life science sectors who require precise metabolic tracing and pharmacokinetic studies.

Application

• As a stable isotope-labeled internal standard for the accurate quantification of N-acetyl-D-mannosamine and sialic acid derivatives in biological matrices via LC-MS/MS.
• Critical reagent in metabolic pathway research, particularly for tracing sialic acid biosynthesis and turnover in cell culture and in vivo studies.
• Use in pharmaceutical R&D for drug metabolism and pharmacokinetic (DMPK) studies of sialic acid-related therapeutics.
• Tool compound for glycobiology research, enabling detailed investigation into glycosylation processes and glycan structure-function relationships.
• Potential application in the development of diagnostic assays for congenital disorders of glycosylation (CDGs).
• Used in the synthesis of deuterated sialic acid analogs for advanced biophysical and structural studies.

Basic Information

Product Name	n-Acetyl-D-Mannosamine-D3
CAS No.	376645-66-8
Molecular Formula	C8H12D3NO6
Molecular Weight	222.21 g/mol (for deuterated form)
Synonyms	N-Acetyl-D-mannosamine-d3; 2-Acetamido-2-deoxy-D-mannose-d3; ManNAc-d3; D-Mannosamine, N-acetyl-, deuterated; N-Acetyl-2-amino-2-deoxy-D-mannopyranose-d3; Acetylmannosamine-d3; 2-(Acetylamino)-2-deoxy-D-mannose-d3; Stable Isotope Labeled N-Acetyl-D-mannosamine
EINECS	Contact for details

Quality Control

Our n-Acetyl-D-Mannosamine-D3 is produced under strict quality management systems to ensure the highest isotopic and chemical purity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (D-enrichment), chemical purity by HPLC, and identity confirmation by NMR and MS. We adhere to cGMP principles for manufacturing critical research biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.