Description

(1,2,3,4-Tetrahydro-1-Oxo-6-Isoquinolinyl)-Boronic Acid is a high-purity boronic acid derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in its role as a versatile intermediate for constructing complex molecules via cross-coupling reactions, particularly the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries engaged in developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and other therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boron-containing partner for palladium-catalyzed carbon-carbon bond formation, enabling the construction of biaryl and heterobiaryl structures.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the isoquinoline scaffold can impart specific biological activity.
• Material Science Precursor: Employed in the synthesis of organic electronic materials, ligands for catalysts, and advanced polymers.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target identification.
• Library Synthesis for High-Throughput Screening: A valuable building block for creating diverse compound libraries to identify new lead structures in drug discovery.

Basic Information

Product Name	(1,2,3,4-Tetrahydro-1-Oxo-6-Isoquinolinyl)-Boronic Acid
CAS No.	376584-81-5
Molecular Formula	C9H10BNO3
Molecular Weight	191.00 g/mol
Synonyms	6-Borono-1,2,3,4-tetrahydroisoquinolin-1-one; 1,2,3,4-Tetrahydro-1-oxo-6-isoquinolineboronic Acid; 1-Oxo-1,2,3,4-tetrahydro-6-isoquinolineboronic Acid; (1-Oxo-1,2,3,4-tetrahydro-6-isoquinolinyl)boronic Acid; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-1(2H)-one (pinacol ester precursor); THIQ-1-one-6-Boronic Acid; 6-Boronotetrahydroisoquinolin-1-one
EINECS	Contact for details

Quality Control

Our (1,2,3,4-Tetrahydro-1-Oxo-6-Isoquinolinyl)-Boronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management standards to support our global clientele in pharmaceutical and fine chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.