Description

5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isoindolin-1-One is a high-purity, advanced pharmaceutical intermediate and building block essential for modern synthetic chemistry. This compound matters because it serves as a key precursor in the synthesis of complex molecules, particularly through Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of carbon-carbon bonds. Pharmaceutical, agrochemical, and advanced materials research and development teams need this high-value boronic ester for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of potential drug candidates, especially those containing the isoindolinone scaffold, for therapeutic areas like oncology and CNS disorders.
• Suzuki-Miyaura Cross-Coupling Reagent: Used as a versatile boronic ester partner for palladium-catalyzed coupling reactions to form biaryl and other complex aromatic structures.
• Agrochemical Synthesis: Employed in the research and development of new active ingredients for crop protection products.
• Material Science Research: Serves as a monomer or functional unit in the development of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Utilized as a linker or functional component in the design of bifunctional molecules for targeted protein degradation.
• Academic & Contract Research: A valuable reagent for methodological development and complex molecule synthesis in university and CRO laboratories.

Basic Information

Product Name	5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isoindolin-1-One
CAS No.	376584-62-2
Molecular Formula	C14H18BNO3
Molecular Weight	259.11 g/mol
Synonyms	1-Oxo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindoline; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-isoindol-1-one; 5-Pinacolatoborylisoindolin-1-one; 5-(Pinacolatoboryl)isoindolin-1-one; Isoindolin-1-one, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 376584-62-2; 5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one
EINECS	Contact for details

Quality Control

Our 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isoindolin-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full analytical data are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature: 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.