Description

2-[[[(1,1-Dimethylethoxy)Carbonyl]Amino]Methyl]-Propanoic-3,3,3-D3 Acid Phenylmethyl Ester is a deuterated, Boc-protected amino acid derivative of significant value in advanced organic synthesis and pharmaceutical research. This compound is specifically engineered to serve as a critical building block for the preparation of isotopically labeled peptides and active pharmaceutical ingredients (APIs), enabling metabolic and pharmacokinetic studies. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who require high-purity, structurally defined intermediates for drug discovery and development.

Application

• Isotope Labeling in Drug Development: A key precursor for synthesizing deuterium-labeled drug candidates to study Absorption, Distribution, Metabolism, and Excretion (ADME) properties.
• Peptide Synthesis Intermediate: Used in solid-phase and solution-phase peptide synthesis to incorporate deuterated amino acid residues into peptide sequences.
• Metabolic Pathway Tracer: Enables the tracing of metabolic pathways and the identification of metabolites in biological systems using mass spectrometry.
• Pharmaceutical Reference Standard: Serves as a high-purity reference material for analytical method development and validation in quality control laboratories.
• Chemical Biology Research: Utilized in proteomics and chemical probe development to investigate protein function and interactions with enhanced analytical sensitivity.
• Organic Synthesis Building Block: Acts as a protected, deuterated synthon for the construction of complex organic molecules in medicinal chemistry.

Basic Information

Product Name	2-[[[(1,1-Dimethylethoxy)Carbonyl]Amino]Methyl]-Propanoic-3,3,3-D3 Acid Phenylmethyl Ester
CAS No.	375379-70-7
Molecular Formula	C16H21D3NO4
Molecular Weight	291.36 g/mol
Synonyms	Boc-β-alanine-d3 benzyl ester; (3,3,3-D3)-3-[[(tert-Butoxycarbonyl)amino]methyl]propanoic acid phenylmethyl ester; Benzyl 3-((tert-butoxycarbonyl)amino)-3,3,3-d3-propionate; N-Boc-3-amino-3,3,3-d3-propionic acid benzyl ester; tert-Butyl (3-(benzyloxy)-1,1,1-d3-3-oxopropyl)carbamate; 3-((tert-Butoxycarbonyl)amino)-3,3,3-d3-propanoic acid benzyl ester; Boc-β-Ala(3,3,3-d3)-OBzl; N-(tert-Butoxycarbonyl)-3-amino-3,3,3-d3-propionic acid benzyl ester
EINECS	Contact for details

Quality Control

Our deuterated chemical intermediates are produced under strict quality management systems to ensure batch-to-batch consistency and high isotopic purity. Each lot of 2-[[[(1,1-Dimethoxy)Carbonyl]Amino]Methyl]-Propanoic-3,3,3-D3 Acid Phenylmethyl Ester is fully characterized by NMR (¹H, ¹³C), HPLC, and mass spectrometry to confirm chemical and isotopic identity, purity, and absence of impurities. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.