Description

Ethyl 2-[(Cyclopropylcarbonyl)Amino]-4-Isobutylthiophene-3-Carboxylate is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, enabling the construction of complex molecular architectures. It is primarily needed by research and development teams, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to innovate and scale new products.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Serves as a key building block for developing new-generation herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science: Used in the research and development of advanced organic electronic materials, such as semiconductors and light-emitting diodes (OLEDs).
• Chemical Synthesis: Functions as a versatile synthon for constructing complex thiophene-containing heterocycles and fused ring systems in academic and industrial R&D.
• Process Development & Scale-up: Supplied to contract development and manufacturing organizations (CDMOs) for process optimization and kilo-lab to pilot-scale production.

Basic Information

Product Name	Ethyl 2-[(Cyclopropylcarbonyl)Amino]-4-Isobutylthiophene-3-Carboxylate
CAS No.	374084-73-8
Molecular Formula	C15H21NO3S
Molecular Weight	295.40 g/mol
Synonyms	Ethyl 2-(cyclopropanecarboxamido)-4-isobutylthiophene-3-carboxylate; 2-[(Cyclopropylcarbonyl)amino]-4-isobutyl-3-thiophenecarboxylic Acid Ethyl Ester; 4-Isobutyl-2-(cyclopropylcarbonylamino)thiophene-3-carboxylic Acid Ethyl Ester; Thiophene-3-carboxylic acid, 2-[(cyclopropylcarbonyl)amino]-4-(2-methylpropyl)-, ethyl ester; 374084-73-8; AKOS BRN 0978; CTK8G0685
EINECS	Contact for details

Quality Control

Our Ethyl 2-[(Cyclopropylcarbonyl)Amino]-4-Isobutylthiophene-3-Carboxylate is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your most demanding R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.