Description

5-(Furan-2-Yl)-1,2,3,4-Tetrahydropyrimido[4',5':4,5]Thieno[2,3-C]Isoquinolin-8(9H)-One is a complex heterocyclic organic compound featuring fused pyrimidine, thiophene, and isoquinoline ring systems, which are of significant interest in advanced pharmaceutical research and development. This structurally unique molecule serves as a critical synthetic intermediate or a pharmacologically active scaffold for creating novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in drug discovery programs targeting a range of diseases.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties.
• Kinase Inhibitor Development: The fused heterocyclic structure makes it a promising precursor for designing potent and selective kinase inhibitors.
• Chemical Biology Probes: Employed in the development of molecular probes to study specific biological pathways and target validation.
• High-Value Fine Chemical Synthesis: Serves as a sophisticated intermediate in multi-step syntheses for complex, high-purity active pharmaceutical ingredients (APIs).
• Academic & Industrial R&D: A valuable compound for exploratory research in organic chemistry and new therapeutic modality development.

Basic Information

Product Name	5-(Furan-2-Yl)-1,2,3,4-Tetrahydropyrimido[4',5':4,5]Thieno[2,3-C]Isoquinolin-8(9H)-One
CAS No.	373377-66-3
Molecular Formula	C₁₉H₁₃N₃O₂S
Molecular Weight	347.39 g/mol
Synonyms	5-(2-Furanyl)-1,2,3,4-tetrahydropyrimido[4',5':4,5]thieno[2,3-c]isoquinolin-8(9H)-one; 5-(Furan-2-yl)-1,2,3,4-tetrahydropyrimido[4',5':4,5]thieno[2,3-c]isoquinolin-8(9H)-one; 373377-66-3; Pyrimidothienoisoquinolinone derivative; Furan-substituted tetrahydropyrimidothienoisoquinolinone
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity essential for research and development. Quality is verified through analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.