Description

1-Hydroxymethyl-1-(Trifluoromethyl)Cyclobutane is a specialized fluorinated cyclobutane derivative that serves as a versatile building block in advanced organic synthesis. Its unique structure, featuring a hydroxymethyl group and a trifluoromethyl group on the same carbon atom, makes it a valuable precursor for introducing the trifluoromethyl moiety into complex molecules, a key modification for enhancing metabolic stability and lipophilicity in pharmaceuticals and agrochemicals. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives where the CF3 group is critical.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group to improve biological activity and environmental profile.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, coatings, and liquid crystals with enhanced chemical resistance and thermal stability.
• Fluorine Chemistry Research: An important reagent in academic and industrial laboratories for studying cyclobutane ring transformations and developing new fluorination methodologies.
• Ligand and Catalyst Development: Utilized to create novel chiral ligands or organocatalysts containing the cyclobutane scaffold for asymmetric synthesis.

Basic Information

Product Name	1-Hydroxymethyl-1-(Trifluoromethyl)Cyclobutane
CAS No.	371917-16-7
Molecular Formula	C6H9F3O
Molecular Weight	154.13 g/mol
Synonyms	(Trifluoromethyl)cyclobutanemethanol; 1-(Trifluoromethyl)cyclobutane-1-methanol; 1-(Hydroxymethyl)-1-(trifluoromethyl)cyclobutane; α-(Trifluoromethyl)cyclobutanemethanol; Cyclobutanemethanol, 1-(trifluoromethyl)-; 1-Trifluoromethyl-1-hydroxymethyl-cyclobutane
EINECS	Contact for details

Quality Control

Our 1-Hydroxymethyl-1-(Trifluoromethyl)Cyclobutane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality assurance supports your R&D and scale-up activities with reliable, specification-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and sources of ignition. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.