Description

3-Mercapto-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a versatile and high-value pyrrolidine-based building block featuring a protected carboxylic acid and a reactive thiol group. This compound is critical for the synthesis of complex molecules where precise stereochemistry and functional group manipulation are required. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for constructing novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of protease inhibitors, enzyme modulators, and other bioactive molecules.
• Peptidomimetics & Constrained Peptides: Used to introduce thiol-functionalized pyrrolidine scaffolds into peptide backbones to enhance stability and biological activity.
• Ligand Synthesis for Catalysis: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Agrochemical Research: Employed in the creation of novel herbicides, fungicides, and plant growth regulators with specific modes of action.
• Material Science: Potential monomer or cross-linking agent in the synthesis of specialty polymers and functional materials.
• Chemical Biology Probes: Useful for creating labeled compounds or affinity probes to study biological pathways and protein interactions.

Basic Information

Item	Detail
Product Name	3-Mercapto-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	371240-66-3
Molecular Formula	C9H17NO2S
Molecular Weight	203.30 g/mol
Synonyms	tert-Butyl 3-mercaptopyrrolidine-1-carboxylate; 1-Boc-3-mercaptopyrrolidine; 3-Mercapto-1-(tert-butoxycarbonyl)pyrrolidine; 1-N-Boc-3-mercaptopyrrolidine; Pyrrolidine-1-carboxylic acid, 3-mercapto-, 1,1-dimethylethyl ester; (R/S)-3-Mercaptopyrrolidine-1-carboxylic acid tert-butyl ester; Boc-3-mercaptopyrrolidine
EINECS	Contact for details

Quality Control

Our 3-Mercapto-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and easily oxidized nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.