Description

cis-8-Boc-3,8-Diazabicyclo[4.2.0]Octane is a high-purity, protected bicyclic diamine building block essential for advanced organic synthesis. This compound matters as a key chiral intermediate in the development of complex pharmaceutical molecules, particularly for active pharmaceutical ingredients (APIs) and drug candidates. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in medicinal chemistry, process development, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral scaffold in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile building block for constructing novel chemical libraries and exploring structure-activity relationships (SAR).
• Process Chemistry Development: Serves as a key starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Ligand and Catalyst Synthesis: Employed in the preparation of chiral ligands and organocatalysts for asymmetric synthesis.
• Peptidomimetics and Bioactive Molecule Design: The bicyclic diamine structure is valuable for creating conformationally constrained analogs of peptides and other bioactive compounds.
• Academic and Industrial R&D: A valuable reagent for exploratory synthesis in both academic laboratories and industrial research centers.

Basic Information

Product Name	cis-8-Boc-3,8-Diazabicyclo[4.2.0]Octane
CAS No.	370881-00-8
Molecular Formula	C12H22N2O2
Molecular Weight	226.32 g/mol
Synonyms	8-(tert-Butoxycarbonyl)-3,8-diazabicyclo[4.2.0]octane; tert-Butyl 3,8-diazabicyclo[4.2.0]octane-8-carboxylate; 3,8-Diazabicyclo[4.2.0]octane, 8-[(1,1-dimethylethoxy)carbonyl]-; Bicyclo[4.2.0]octane, 8-(tert-butoxycarbonyl)-3,8-diaza-; 8-Boc-3,8-diazabicyclo[4.2.0]octane; Boc-protected diazabicyclooctane; cis-Boc-DABCO derivative
EINECS	Contact for details

Quality Control

Our cis-8-Boc-3,8-Diazabicyclo[4.2.0]Octane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC for assay and chiral purity, to meet the stringent requirements of pharmaceutical R&D and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.