Description

tert-Butyl 3-Mercaptopyridin-4-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate featuring a unique pyridine-thiol-carbamate structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug development programs. It is primarily utilized by pharmaceutical R&D departments, fine chemical manufacturers, and contract research organizations (CROs) requiring a reliable and high-quality building block for complex organic synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel kinase inhibitors and targeted cancer therapies.
• Antiviral Drug Development: Used in research and production of antiviral compounds, leveraging its heterocyclic scaffold.
• Chemical Biology & Proteomics: Serves as a precursor for synthesizing probes and ligands used in target identification and validation studies.
• Custom Synthesis & Medicinal Chemistry: Employed in lead optimization and structure-activity relationship (SAR) studies for new drug candidates.
• Fine Chemical Manufacturing: Integrated into multi-step synthesis processes for producing high-value specialty chemicals.

Basic Information

Product Name	tert-Butyl 3-Mercaptopyridin-4-Ylcarbamate
CAS No.	365996-04-9
Molecular Formula	C10H14N2O2S
Molecular Weight	226.30 g/mol
Synonyms	4-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-pyridinethiol; tert-Butyl N-(3-mercaptopyridin-4-yl)carbamate; 3-Mercapto-4-pyridinylcarbamic Acid tert-Butyl Ester; 4-Amino-3-mercaptopyridine tert-Butyl Carbamate; tert-Butyl (3-mercaptopyridin-4-yl)carbamate; 4-(tert-Butoxycarbonylamino)pyridine-3-thiol; BOC-3-Mercapto-4-aminopyridine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Mercaptopyridin-4-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specifications and test results. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This material is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.