Description

3-(1-Methyl-1H-Indol-3-Yl)-4-[1-[1-(2-Pyridinylmethyl)-4-Piperidinyl]-1H-Indol-3-Yl]-1H-Pyrrole-2,5-Dione Hydrochloride is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate of significant interest in pharmaceutical research and development. This compound is critical for the synthesis of novel therapeutic agents targeting viral infections, offering a sophisticated chemical scaffold for drug discovery. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic laboratories engaged in antiviral and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of next-generation non-nucleoside reverse transcriptase inhibitors (NNRTIs) for antiviral therapies.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery projects.
• Antiviral Drug Development: Essential for research programs focused on HIV and other retroviral infections.
• Biochemical Assays: Serves as a reference standard or inhibitor in enzymatic assays targeting reverse transcriptase activity.
• Contract Manufacturing: Supplied to CDMOs for the scale-up and cGMP production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university laboratories for studying enzyme inhibition mechanisms and novel therapeutic pathways.

Basic Information

Product Name	3-(1-Methyl-1H-Indol-3-Yl)-4-[1-[1-(2-Pyridinylmethyl)-4-Piperidinyl]-1H-Indol-3-Yl]-1H-Pyrrole-2,5-Dione Hydrochloride
CAS No.	365253-37-8
Molecular Formula	C33H30ClN5O2
Molecular Weight	564.08 g/mol
Synonyms	L-870,810; L870810; L 870810; 1H-Pyrrole-2,5-dione, 3-(1-methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-, hydrochloride (1:1); NNRTI Intermediate L-870,810; 3-(1-Methylindol-3-yl)-4-[1-[1-(pyridin-2-ylmethyl)piperidin-4-yl]indol-3-yl]-1H-pyrrole-2,5-dione hydrochloride
EINECS	Contact for details

Quality Control

Our 3-(1-Methyl-1H-Indol-3-Yl)-4-[1-[1-(2-Pyridinylmethyl)-4-Piperidinyl]-1H-Indol-3-Yl]-1H-Pyrrole-2,5-Dione Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.