Description

2-{3-Bromo-5-Ethoxy-4-[(2-Fluorobenzyl)Oxy]Phenyl}-5,6,7,8-Tetrahydro[1]Benzothieno[2,3-D]Pyrimidin-4(3H)-One is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel therapeutic agents. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology and anti-inflammatory research.
• Kinase Inhibitor Research: Serves as a core scaffold or precursor for the development of potent and selective kinase inhibitors due to its benzothienopyrimidine structure.
• Medicinal Chemistry & SAR Studies: Used extensively in structure-activity relationship (SAR) studies to optimize drug potency, selectivity, and pharmacokinetic properties.
• Biochemical Assay Development: Employed as a reference standard or probe compound in high-throughput screening and biochemical assays.
• Contract Research & Development (CRO/CMO): Supplied to contract research and manufacturing organizations supporting global drug discovery pipelines.
• Academic Research: Utilized in university and institutional labs for cutting-edge research in chemical biology and drug discovery methodologies.

Basic Information

Product Name	2-{3-Bromo-5-Ethoxy-4-[(2-Fluorobenzyl)Oxy]Phenyl}-5,6,7,8-Tetrahydro[1]Benzothieno[2,3-D]Pyrimidin-4(3H)-One
CAS No.	364625-71-8
Molecular Formula	C27H24BrFN2O3S
Molecular Weight	555.46 g/mol
Synonyms	2-(3-Bromo-5-ethoxy-4-((2-fluorobenzyl)oxy)phenyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one; 2-[3-Bromo-5-ethoxy-4-[(2-fluorophenyl)methoxy]phenyl]-3,5,6,7,8,8a-hexahydro-1H-benzothieno[2,3-d]pyrimidin-4-one; CAS 364625-71-8; Benzothienopyrimidinone derivative; Kinase inhibitor intermediate; BTT-Pyrimidinone derivative.
EINECS	Contact for details

Quality Control

Our 2-{3-Bromo-5-Ethoxy-4-[(2-Fluorobenzyl)Oxy]Phenyl}-5,6,7,8-Tetrahydro[1]Benzothieno[2,3-D]Pyrimidin-4(3H)-One is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profile is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.