Description

2-Boc-6-Hydroxy-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is a key Boc-protected heterocyclic building block used in advanced organic synthesis. This compound is critical for researchers and manufacturers requiring high-purity intermediates for the development of complex molecules. It is primarily utilized in pharmaceutical R&D and fine chemical synthesis, particularly for constructing isoquinoline-based scaffolds found in active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of isoquinoline-based drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetic Chemistry: Used in the design and synthesis of peptide analogs and constrained scaffolds for medicinal chemistry applications.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group provides orthogonal protection for the amine functionality in multi-step synthetic sequences.
• Chemical Biology Probes: Serves as a precursor for developing molecular probes and tool compounds for biological target validation.
• Fine Chemical Synthesis: Employed in the custom synthesis of complex heterocycles for agrochemicals, materials science, and specialty chemicals.
• Academic & Industrial R&D: A valuable reagent for research laboratories focused on novel synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	2-Boc-6-Hydroxy-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid
CAS No.	362492-00-0
Molecular Formula	C₁₅H₁₉NO₅
Molecular Weight	293.31 g/mol
Synonyms	1,2,3,4-Tetrahydro-6-hydroxy-1-isoquinolinecarboxylic acid 2-(1,1-dimethylethyl) ester; 2-(tert-Butoxycarbonyl)-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 2-Boc-6-OH-Tic-OH; 6-Hydroxy-2-[(2-methylpropan-2-yl)oxycarbonyl]-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; 2-Boc-6-hydroxy-TIQ-1-COOH; Boc-6-hydroxy-Tic-OH; 2-(Boc-amino)-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2-Boc-6-Hydroxy-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and desiccated after opening to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.