Description

L-Leucine-3,3-D2 is a stable isotope-labeled analog of the essential amino acid L-leucine, specifically deuterated at the 3,3-positions. This compound is critical for advanced research and analytical applications where precise molecular tracking and quantification are required. It is primarily utilized by pharmaceutical researchers, metabolic scientists, and analytical laboratories engaged in mass spectrometry, NMR spectroscopy, and pharmacokinetic studies.

Application

• Internal Standard in Mass Spectrometry (MS): Serves as a crucial quantitative reference in LC-MS and GC-MS analysis for accurate measurement of endogenous L-leucine levels in biological matrices.
• Metabolic Pathway Tracing: Used in stable isotope labeling studies to investigate protein synthesis rates, amino acid metabolism, and nutrient utilization in cell cultures, animal models, and clinical research.
• NMR Spectroscopy Studies: Provides a non-radioactive tracer for elucidating molecular structures, dynamics, and reaction mechanisms in biochemical and pharmaceutical research.
• Pharmaceutical Development: Employed in the research and development of new drugs, particularly in studying drug metabolism, bioavailability, and pharmacokinetics (DMPK).
• Nutritional and Biomedical Research: Facilitates studies on muscle protein metabolism, metabolic disorders, and the impact of dietary interventions.
• Isotope Dilution Analysis: Enables highly accurate and precise quantification of L-leucine in complex samples, enhancing data reliability in analytical chemistry.

Basic Information

Product Name	L-Leucine-3,3-D2
CAS No.	362049-59-0
Molecular Formula	C6H11D2NO2
Molecular Weight	133.19 g/mol (approx.)
Synonyms	(2S)-2-Amino-4-methyl-3,3-dideuteropentanoic acid; L-Leucine-3,3-d2; (S)-2-Amino-4-methyl-3,3-d2-pentanoic acid; Leucine-3,3-d2; (S)-Leucine-3,3-d2; 3,3-Dideutero-L-leucine; Deuterated L-leucine; Stable Isotope Labeled L-Leucine
EINECS	Contact for details

Quality Control

Our L-Leucine-3,3-D2 is manufactured under strict quality systems to ensure high isotopic and chemical purity, essential for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % D), chemical purity (by HPLC), chiral purity, and residual solvent content. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (Atom % D)	≥ 98%
Assay (HPLC)	≥ 98.0%
Chiral Purity ([α]D)	≥ 99.0% L-isomer
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.