Description

D-Phenyl-D5-Alanine is a stable isotope-labeled analog of the essential amino acid L-phenylalanine, where five hydrogen atoms are replaced by deuterium. This high-purity compound is critical for advanced research and development requiring precise metabolic and pharmacokinetic tracing. It is primarily utilized by pharmaceutical, biotechnology, and academic research institutions engaged in drug discovery, proteomics, and metabolic studies where exceptional isotopic enrichment and chemical purity are non-negotiable.

Application

• Internal Standard for Mass Spectrometry: Serves as a quantitative reference standard in LC-MS and GC-MS analyses for accurate measurement of phenylalanine and related metabolites in complex biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracer studies to elucidate the absorption, distribution, metabolism, and excretion (ADME) profiles of new drug candidates.
• Proteomics and Metabolic Research: Enables stable isotope labeling in amino acids (SILAA) for protein turnover studies and metabolic pathway analysis.
• NMR Spectroscopy: Acts as a deuterated probe in nuclear magnetic resonance studies to simplify spectra and investigate molecular structure and dynamics.
• Pharmaceutical Reference Standard: Employed in the quality control and validation of analytical methods for pharmaceutical formulations.
• Biochemical Research: Used in enzymatic studies and as a building block for synthesizing deuterated peptides and more complex biomolecules.

Basic Information

Item	Details
Product Name	D-Phenyl-D5-Alanine
CAS No.	362049-55-6
Molecular Formula	C9H6D5NO2
Molecular Weight	171.21 g/mol
Synonyms	(2R)-2-Amino-3-(2,3,4,5,6-pentadeuteriophenyl)propanoic acid; D-Phenylalanine-2,3,4,5,6-d5; D-Phenylalanine-d5; (R)-2-Amino-3-(pentadeuteriophenyl)propanoic acid; Deuterated D-Phenylalanine; D-Phe-d5; D-β-Phenyl-d5-alanine
EINECS	Contact for details

Quality Control

Our D-Phenyl-D5-Alanine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % D), chemical purity, and chiral purity. We support research and regulatory requirements with documentation traceable to international standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.