Description

4-Hydroxy-2,2,3,3,4,4-Hexadeuterobutyric Acid Sodium Salt is a high-purity, deuterium-labeled derivative of sodium 4-hydroxybutyrate, a compound of significant interest in biochemical and pharmaceutical research. This product matters for its role as a stable isotope-labeled internal standard, enabling precise quantitative analysis in complex biological matrices via mass spectrometry. It is essential for researchers and quality control laboratories in the pharmaceutical, forensic toxicology, and metabolic research sectors who require uncompromised accuracy in their analytical methods.

Application

• Used as a stable isotope-labeled internal standard (SIL-IS) for the accurate quantification of GHB (γ-hydroxybutyrate) and related compounds in LC-MS/MS and GC-MS analyses.
• Critical for forensic and clinical toxicology testing, ensuring reliable results in drug-facilitated crime investigations and overdose cases.
• Facilitates pharmacokinetic and metabolic studies in pharmaceutical R&D, tracing the absorption, distribution, metabolism, and excretion of drug candidates.
• Supports quality control and method validation in analytical laboratories to meet stringent regulatory standards (e.g., FDA, EMA).
• Enables research into the GABAergic system and neurological disorders where GHB plays a role.
• Employed in the synthesis of other deuterium-labeled fine chemicals and active pharmaceutical ingredients (APIs) for advanced research applications.

Basic Information

Product Name	4-Hydroxy-2,2,3,3,4,4-Hexadeuterobutyric Acid Sodium Salt
CAS No.	362049-53-4
Molecular Formula	C4D6H2NaO3
Molecular Weight	130.10 g/mol
Synonyms	Sodium 4-Hydroxy-2,2,3,3,4,4-d6-butyrate; Sodium 4-Hydroxybutyrate-d6; GHB-d6 Sodium Salt; Sodium Oxybate-d6; 4-Hydroxy-d6-butyric Acid Sodium Salt; Sodium 4-Hydroxy-d6-butyrate; 4-Hydroxybutanoic-2,2,3,3,4,4-d6 Acid Sodium Salt
EINECS	Contact for details

Quality Control

Our deuterium-labeled compounds are manufactured under strict quality systems to ensure the highest isotopic and chemical purity for critical research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing specifications for isotopic enrichment, chemical purity (by HPLC/NMR), and identity confirmation. We support GMP/GLP-compliant research and can provide materials suitable for regulatory submission support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.