Description

2'-Fluorodeoxyuridine-5,6-D2 is a deuterated analog of the nucleoside derivative 2'-Fluorodeoxyuridine, a compound of significant interest in biochemical and pharmaceutical research. This deuterated version is specifically designed for use as an internal standard in mass spectrometry, enabling precise quantification and metabolic pathway tracing in complex biological matrices. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and academic sectors who require high-fidelity analytical standards for drug metabolism and pharmacokinetic (DMPK) studies.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, non-interfering internal standard for the accurate quantification of 2'-Fluorodeoxyuridine and related metabolites in bioanalytical assays.
• Drug Metabolism Studies (DMPK): Used in tracing metabolic pathways, studying isotope effects, and investigating the pharmacokinetic profile of fluorinated nucleoside drugs.
• Pharmaceutical R&D: Critical for the development and validation of analytical methods during the drug discovery and development process for antiviral or anticancer nucleoside analogs.
• Isotope Labeling Research: Serves as a deuterium-labeled building block or probe in mechanistic studies and stable isotope labeling experiments.
• Quality Control & Reference Standard: Employed by API manufacturers and QC labs to ensure batch-to-batch consistency and purity of active pharmaceutical ingredients.

Basic Information

Product Name	2'-Fluorodeoxyuridine-5,6-D2
CAS No.	362049-50-1
Molecular Formula	C9H9D2FN2O5
Molecular Weight	248.20 g/mol (for deuterated form)
Synonyms	2'-Fluoro-2'-deoxyuridine-5,6-D2; 5,6-Dideutero-2'-fluoro-2'-deoxyuridine; 2'-F-dUrd-5,6-D2; 1-((2R,4S,5R)-4-Fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5,6-dideuteropyrimidine-2,4(1H,3H)-dione; 2'-Fluoro-5,6-dideutero-2'-deoxyuridine; FDURD-5,6-D2; Deuterated 2'-FdUrd
EINECS	Contact for details

Quality Control

Every batch of 2'-Fluorodeoxyuridine-5,6-D2 is produced and analyzed under strict quality management protocols. We provide comprehensive Certificates of Analysis (COA) that detail purity, isotopic enrichment, and impurity profiles. Our quality systems are designed to meet the rigorous standards required for analytical reference materials and pharmaceutical research, ensuring traceability and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (H-NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D-content, MS)	≥ 98 atom % D (at positions 5 & 6)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.