Description

Tryptamine-Alpha,α-D2 Hcl is a deuterated derivative of tryptamine hydrochloride, where two hydrogen atoms at the alpha position are replaced with deuterium. This isotopic labeling is crucial for enhancing the precision and reliability of analytical methods, particularly in mass spectrometry. It serves as a key intermediate and reference standard for researchers and manufacturers in the pharmaceutical and life sciences sectors, enabling advanced studies in drug metabolism, pharmacokinetics, and neurochemical research.

Application

• Internal Standard for LC-MS/MS: Used as a stable isotope-labeled internal standard for the quantitative bioanalysis of tryptamine and related indolealkylamines, ensuring high accuracy and reproducibility in mass spectrometry.
• Metabolic Pathway Tracing: Employed in drug metabolism and pharmacokinetic (DMPK) studies to trace and quantify metabolites, leveraging the deuterium label for distinct mass spectral signatures.
• Neurochemical Research: Acts as a biochemical tool in neuroscience for investigating the role of tryptamine and its analogs in serotonergic and other neurological pathways.
• Pharmaceutical Intermediate: Serves as a specialized building block in the synthesis of novel deuterated drug candidates, where deuterium incorporation can improve metabolic stability and pharmacokinetic profiles.
• Reference Material: Provides a certified reference material for quality control and method validation in analytical laboratories to comply with GLP and GMP standards.

Basic Information

Product Name	Tryptamine-Alpha,α-D2 Hcl
CAS No.	362049-49-8
Molecular Formula	C₁₀H₁₁D₂N₂·HCl
Molecular Weight	202.72 g/mol (for monoisotopic)
Synonyms	2-(1H-Indol-3-yl)ethan-1,1-d2-amine hydrochloride; Tryptamine-α,α-d2 hydrochloride; 3-(2-Amino-1,1-d2-ethyl)-1H-indole hydrochloride; Deuterated Tryptamine HCl; [1,1-²H₂]Tryptamine hydrochloride; Tryptamine-d2 HCl; α,α-Dideuterotryptamine hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Tryptamine-Alpha,α-D2 Hcl is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment meet stringent specifications. Our quality assurance protocol includes advanced techniques such as NMR, HPLC, and mass spectrometry to verify chemical and isotopic purity. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.