Description

(1S,3S,5S)-3-(Aminocarbonyl)-2-Azabicyclo[3.1.0]Hexane-2-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a constrained bicyclic scaffold. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic disorders. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics and process chemistry optimization.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug candidates, particularly for central nervous system (CNS) targets.
• Protease Inhibitor Research: Serves as a core structural motif in the development of novel protease inhibitors for antiviral and anticancer applications.
• Peptidomimetic Chemistry: Used to construct conformationally restricted peptide analogs to enhance metabolic stability and receptor selectivity.
• Medicinal Chemistry & SAR Studies: Provides a versatile scaffold for structure-activity relationship (SAR) studies to optimize drug potency and pharmacokinetic properties.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes for commercial API manufacturing.
• Contract Research & Development (CRO/CDMO): Supplied to organizations specializing in custom synthesis and early-stage drug development projects.

Basic Information

Product Name	(1S,3S,5S)-3-(Aminocarbonyl)-2-Azabicyclo[3.1.0]Hexane-2-Carboxylic Acid tert-Butyl Ester
CAS No.	361440-67-7
Molecular Formula	C11H18N2O3
Molecular Weight	226.27 g/mol
Synonyms	2-Azabicyclo[3.1.0]hexane-2-carboxylic acid, 3-(aminocarbonyl)-, 1,1-dimethylethyl ester, (1S,3S,5S)-; tert-Butyl (1S,3S,5S)-3-carbamoyl-2-azabicyclo[3.1.0]hexane-2-carboxylate; (1S,3S,5S)-3-Carbamoyl-2-azabicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester; Bicyclo[3.1.0]hexane-2-carboxamide derivative; CAS 361440-67-7; tert-Butyl 3-carbamoyl-2-azabicyclo[3.1.0]hexane-2-carboxylate (stereoisomer)
EINECS	Contact for details

Quality Control

Our production of (1S,3S,5S)-3-(Aminocarbonyl)-2-Azabicyclo[3.1.0]Hexane-2-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and conformity to client specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.