Description

[[4-(Trifluoromethyl)Cyclohexyl]Methyl]Amine (cis- And trans- Mixture) is a versatile fluorinated amine building block characterized by its cyclohexyl backbone and trifluoromethyl group. This compound is valued for its ability to impart unique physicochemical properties, such as enhanced lipophilicity and metabolic stability, into target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed as a functional monomer or cross-linking agent to introduce amine functionality and fluorine atoms into specialty polymers, enhancing their chemical resistance and surface properties.
• Organic Synthesis Building Block: Utilized in various organic transformations, including reductive amination, amide coupling, and as a precursor for heterocycle formation in complex molecule assembly.
• Catalyst Ligand Precursor: Can be derivatized to create novel ligands for asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	[[4-(Trifluoromethyl)Cyclohexyl]Methyl]Amine (cis- And trans- Mixture)
CAS No.	361393-85-3
Molecular Formula	C8H14F3N
Molecular Weight	181.20 g/mol
Synonyms	4-(Trifluoromethyl)cyclohexanemethanamine; (4-(Trifluoromethyl)cyclohexyl)methanamine; 1-[[4-(Trifluoromethyl)cyclohexyl]methyl]amine; 4-(Trifluoromethyl)cyclohexylmethylamine; 4-(Trifluoromethyl)cyclohexanemethylamine; 4-(Trifluoromethyl)cyclohexylmethanamine; 4-(Trifluoromethyl)cyclohexylmethylamine (cis- and trans- mixture); Aminomethyl-4-(trifluoromethyl)cyclohexane
EINECS	Contact for details

Quality Control

Our [[4-(Trifluoromethyl)Cyclohexyl]Methyl]Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, isomeric ratio, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and acids. Due to its basic nature and compatibility with organic solvents, ensure containers are kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Isomeric Ratio (cis/trans)	Typically ~1:1 mixture (Contact for specific batch data)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.