Description

α-Ketoisovaleric Acid-3-D Sodium Salt is a high-purity, isotopically labeled sodium salt of the key metabolic intermediate α-ketoisovaleric acid. This compound matters for researchers and manufacturers requiring precise metabolic pathway tracing and stable isotope dilution analysis in complex biological systems. It is primarily needed by the pharmaceutical, biotechnology, and advanced life science research sectors for applications in drug metabolism studies, proteomics, and the synthesis of labeled compounds.

Application

• Stable Isotope Labeling in Metabolic Flux Analysis (MFA): Used as a 13C or 2H (Deuterium) labeled tracer to quantitatively map carbon and hydrogen flow in central metabolic pathways of cells and microorganisms.
• Internal Standard for Mass Spectrometry: Serves as a critical internal standard in LC-MS and GC-MS assays for the accurate quantification of endogenous α-ketoisovaleric acid and related metabolites in biofluids and tissue samples.
• Precursor for Labeled Amino Acid Synthesis: Acts as a key biochemical precursor in the enzymatic or chemical synthesis of isotopically labeled valine and other branched-chain amino acids.
• In Vitro Diagnostic (IVD) Reagent Manufacturing: Incorporated into calibrators and controls for clinical diagnostic kits targeting inborn errors of metabolism, such as Maple Syrup Urine Disease (MSUD).
• Biochemical Research on Branched-Chain Amino Acid Metabolism: Facilitates studies on enzyme kinetics (e.g., branched-chain α-keto acid dehydrogenase complex), metabolic disorders, and cellular energy regulation.
• Pharmaceutical Impurity Profiling and Degradation Studies: Employed as a reference standard to identify and quantify process-related impurities or degradation products in drug substances and products.

Basic Information

Item	Detail
Product Name	α-Ketoisovaleric Acid-3-D Sodium Salt
CAS No.	360769-16-0
Molecular Formula	C5H6DNaO3 • xH2O
Molecular Weight	Contact for details
Synonyms	2-Oxoisovaleric Acid-3-d Sodium Salt; 3-Methyl-2-oxobutyric Acid-3-d Sodium Salt; Sodium 2-Keto-3-methylbutyrate-3-d; α-Ketoisovalerate-3-d Sodium Salt; 2-Ketoisovaleric Acid-3-D Sodium Salt; 3-Deutero-3-methyl-2-oxobutanoic Acid Sodium Salt; Sodium 3-Deutero-3-methyl-2-oxobutanoate
EINECS	Contact for details

Quality Control

Our α-Ketoisovaleric Acid-3-D Sodium Salt is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and mass spectrometry, to confirm isotopic enrichment and chemical purity. Certificates of Analysis (COA) detailing isotopic purity (e.g., D-atom %), chemical purity, and other critical parameters are available upon request to ensure it meets your specific research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry place. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Isotopic Purity (D-atom %)	≥ 98% (or as specified)
Chemical Purity (HPLC)	≥ 95%
Water Content (KF)	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.