Description

Maropitant Citrate Hydrate is a potent and selective neurokinin-1 (NK1) receptor antagonist. This compound is of significant commercial and therapeutic importance as the active pharmaceutical ingredient in veterinary antiemetic medications. It is primarily required by manufacturers in the animal health pharmaceutical sector for the formulation of products designed to prevent acute vomiting and manage motion sickness in dogs and cats.

Application

• Active Pharmaceutical Ingredient (API) in veterinary injectable and tablet formulations.
• Key component in antiemetic drugs for the prevention of acute vomiting in dogs.
• Critical material for medications targeting the prevention of vomiting due to motion sickness in pets.
• Used in veterinary research and development for studying NK1 receptor pathways.
• Essential for compounding pharmacies specializing in veterinary medicine.
• Raw material for manufacturers of generic veterinary pharmaceutical products.

Basic Information

Product Name	Maropitant Citrate Hydrate
CAS No.	359875-09-5
Molecular Formula	C32H39N3O2 • C6H8O7 • xH2O
Molecular Weight	678.76 g/mol (anhydrous free base citrate)
Synonyms	Maropitant Citrate; Maropitant Citrate Monohydrate; (2S,3S)-2-Benzhydryl-N-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine citrate salt hydrate; Cerenia (Brand Name API); NK1 Receptor Antagonist; SC-002426; PF-00368760
EINECS	Contact for details

Quality Control

Our Maropitant Citrate Hydrate is manufactured under strict quality systems suitable for pharmaceutical use. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and strength. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with in-house specifications aligned with ICH Q3 guidelines for impurities. We support audits and can provide Drug Master File (DMF) information as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	2.0% - 6.0%
Related Substances (HPLC)	Individual unknown impurity: NMT 0.10% Total impurities: NMT 1.0%
Residual Solvents (GC)	Complies with ICH Q3C Class 2 & 3 limits
Heavy Metals	< 20 ppm
Specific Rotation	Contact for details
Microbiological Enumeration	Total aerobic microbial count < 1000 cfu/g

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.