Description

3(5H)-Indolizinone,6,7,8,8A-Tetrahydro-,(8As)-(9Ci) is a high-purity, advanced pharmaceutical intermediate belonging to the indolizinone class of heterocyclic compounds. Its defined stereochemistry and complex fused-ring structure make it a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs). This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in areas requiring sophisticated chiral scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the multi-step synthesis of potential drug candidates targeting central nervous system (CNS) disorders, inflammation, or infectious diseases.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Asymmetric Synthesis: Employed in catalytic asymmetric reactions due to its stereogenic center, facilitating the construction of complex molecules with high enantiomeric purity.
• Chemical Biology Probes: Utilized in the development of molecular probes to study biological pathways and protein functions.
• Process Chemistry Development: Acts as a critical intermediate for scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.

Basic Information

Product Name	3(5H)-Indolizinone,6,7,8,8A-Tetrahydro-,(8As)-(9Ci)
CAS No.	359866-35-6
Molecular Formula	C8H11NO
Molecular Weight	137.18 g/mol
Synonyms	(8aS)-6,7,8,8a-Tetrahydro-3(5H)-indolizinone; (8aS)-Octahydro-3H-indolizin-3-one; 3(5H)-Indolizinone, 6,7,8,8a-tetrahydro-, (8aS)-; 359866-35-6; (8aS)-3-Oxo-octahydroindolizine; (8aS)-Hexahydro-1H-pyrrolizin-3(2H)-one
EINECS	Contact for details

Quality Control

Our production of 3(5H)-Indolizinone,6,7,8,8A-Tetrahydro-,(8As)-(9Ci) adheres to stringent quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure identity, purity, and stereochemical integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our facilities and processes are designed to meet the rigorous standards required for pharmaceutical R&D and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.