Description

4-Hydroxy-1-(3-Pyridyl)-1-Butanone (3,3,4,4-D4) is a deuterium-labeled derivative of a key pyridine-based intermediate. This compound matters for its utility as a stable isotope-labeled internal standard in quantitative analytical methods, ensuring precise and reliable measurements. It is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for advanced drug metabolism and pharmacokinetic (DMPK) studies, as well as for quality control in synthesis.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated standard for the accurate quantification of its non-labeled counterpart and related metabolites in biological matrices.
• Pharmaceutical Research: Critical for drug metabolism studies (DMPK), bioavailability testing, and pharmacokinetic profiling in preclinical and clinical development.
• Metabolite Identification: Aids in the identification and structural elucidation of drug metabolites using mass spectrometry.
• Chemical Synthesis Intermediate: Serves as a specialized building block for the synthesis of deuterium-labeled target molecules in medicinal chemistry.
• Analytical Reference Standard: Provides a certified reference material for calibrating instruments and validating analytical methods in quality control laboratories.

Basic Information

Product Name	4-Hydroxy-1-(3-Pyridyl)-1-Butanone (3,3,4,4-D4)
CAS No.	359435-75-9
Molecular Formula	C9H7D4NO2
Molecular Weight	169.21 g/mol (approx.)
Synonyms	4-Hydroxy-1-(pyridin-3-yl)butan-1-one-d4; 1-(3-Pyridinyl)-4-hydroxy-1-butanone-d4; 3-Pyridyl 4-hydroxybutyl ketone-d4; 4-Hydroxy-1-(3-pyridinyl)-1-butanone-d4; Deuterated 4-Hydroxy-1-(3-Pyridyl)-1-Butanone; [3,3,4,4-2H4]-4-Hydroxy-1-(3-pyridyl)butan-1-one
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality management to ensure high isotopic purity and chemical integrity, essential for reliable analytical results. Each batch is characterized by advanced spectroscopic techniques including NMR and Mass Spectrometry. Certificates of Analysis (COA) detailing isotopic enrichment (D%), chemical purity, and analytical data are provided to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed to protect the deuterated compound from moisture absorption and potential contamination.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D%)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.