Description

Dl-Phenyl-D5-Glycine is a stable isotope-labeled analog of the amino acid derivative phenylglycine, where five hydrogen atoms are replaced by deuterium. This deuteration is critical for applications requiring minimal interference from background signals, providing a distinct mass spectral signature. It is primarily utilized by researchers and manufacturers in the pharmaceutical and analytical chemistry sectors for use as an internal standard, a tracer in metabolic studies, or a building block in the synthesis of deuterated active pharmaceutical ingredients (APIs).

Application

• Internal standard for the precise quantification of phenylglycine and related compounds in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS).
• Deuterated tracer in pharmacokinetic and drug metabolism studies to track the absorption, distribution, metabolism, and excretion (ADME) of pharmaceutical compounds.
• Key synthetic intermediate for the preparation of deuterium-labeled pharmaceutical molecules, enhancing drug discovery and development.
• Use in NMR spectroscopy as a tool for mechanistic studies and structural elucidation where proton-deuterium exchange is relevant.
• Component in the development of diagnostic assays and reference materials requiring high specificity and accuracy.

Basic Information

Product Name	Dl-Phenyl-D5-Glycine
CAS No.	358731-96-1
Molecular Formula	C8D5H4NO2
Molecular Weight	~171.19 g/mol
Synonyms	(±)-2-Amino-2-(2,3,4,5,6-pentadeuteriophenyl)acetic acid; DL-α-Amino-2,3,4,5,6-pentadeuteriobenzeneacetic acid; (RS)-2-Amino-2-(pentadeuteriophenyl)acetic acid; Phenyl-d5-glycine; Glycine, N-(phenyl-d5)-; DL-Phenyl-d5-glycine; 2,3,4,5,6-Pentadeuterio-DL-phenylglycine
EINECS	Contact for details

Quality Control

Our Dl-Phenyl-D5-Glycine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure high chemical purity and isotopic enrichment, typically exceeding 98% (chemical purity) and 98 atom % D. A Certificate of Analysis (COA) detailing specifications for assay, isotopic purity, residual solvents, and identity is provided with every shipment to guarantee traceability and batch-to-batch consistency for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Chemical Purity	≥ 98%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.