Description

Sodium 4-Hydroxybutyrate-3,3,4,4-D4 is a high-purity, isotopically labeled derivative of sodium γ-hydroxybutyrate (GHB). This compound is a critical analytical standard and research chemical, distinguished by its deuterium atoms at the 3,3,4,4 positions, which provide a stable isotopic signature for precise quantification and metabolic pathway tracing. It is essential for researchers and quality control laboratories in the pharmaceutical, forensic, and clinical diagnostics sectors who require definitive reference materials for method development, validation, and regulatory compliance. The product is supplied under stringent quality controls to ensure batch-to-batch consistency and data integrity.

Application

• Internal Standard for Quantitative Analysis: Used as a deuterated internal standard in LC-MS/MS and GC-MS methods for the accurate quantification of GHB and related metabolites in biological matrices (e.g., plasma, urine, hair).
• Metabolic and Pharmacokinetic Studies: Enables detailed investigation of the absorption, distribution, metabolism, and excretion (ADME) profile of GHB in preclinical and clinical research.
• Forensic Toxicology and Doping Control: Serves as a certified reference material (CRM) for the unambiguous identification and confirmation of GHB in forensic toxicology, workplace drug testing, and anti-doping programs.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of potential impurities or degradation products in pharmaceutical formulations containing related compounds.
• Stable Isotope Labeling Experiments (SILE): Facilitates advanced research in neurochemistry and sleep studies by tracing the biochemical fate of GHB with high specificity.
• Method Development and Validation: Critical for developing, optimizing, and validating highly sensitive and selective analytical methods in compliance with FDA, EMA, and other regulatory guidelines.

Basic Information

Product Name	Sodium 4-Hydroxybutyrate-3,3,4,4-D4
CAS No.	358730-90-2
Molecular Formula	C4H3D4NaO3
Molecular Weight	130.12 g/mol (for labeled form)
Synonyms	Sodium 4-Hydroxy[3,3,4,4-2H4]butyrate; Sodium γ-Hydroxybutyrate-d4; GHB-d4 Sodium Salt; Sodium Oxybate-d4; 4-Hydroxybutyric Acid-d4 Sodium Salt; Sodium 4-Hydroxybutanoate-3,3,4,4-d4; [3,3,4,4-2H4]-GHB Sodium Salt
EINECS	Contact for details

Quality Control

Every batch of Sodium 4-Hydroxybutyrate-3,3,4,4-D4 is manufactured and analyzed under a strict quality management system. The product undergoes comprehensive testing to ensure high chemical purity, isotopic enrichment, and chromatographic suitability for use as a reference standard. Identity is confirmed by NMR and mass spectrometry, while purity and isotopic purity are determined by validated HPLC and LC-MS methods. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results for all critical parameters. Our quality processes support compliance with cGMP and ISO 17034 guidelines for reference material producers.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry place. This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a desiccated environment to prevent absorption of moisture, which can affect stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0% at designated positions
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.