Description

4-Phenylbutyric-D11 Acid is a stable isotope-labeled analog of 4-phenylbutyric acid, where eleven hydrogen atoms are replaced by deuterium. This high-purity compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring analytical accuracy and reliability. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and chemical analysis sectors for method development, pharmacokinetic studies, and metabolic research.

Application

• Mass Spectrometry Internal Standard: Serves as a critical reference compound for the precise quantification of 4-phenylbutyric acid and related metabolites in biological matrices via LC-MS/MS and GC-MS.
• Pharmaceutical Research: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion (ADME) of pharmaceutical compounds.
• Biochemical Research: Employed as a tracer in metabolic pathway analysis and proteomics research to investigate cellular processes and protein function.
• Analytical Method Development: Essential for developing and validating highly sensitive and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Quality Control & Assurance: Acts as a certified reference material (CRM) in quality control laboratories to ensure the accuracy and consistency of analytical results.
• Clinical Diagnostics: Potential use in developing diagnostic assays for monitoring inborn errors of metabolism and other disorders.

Basic Information

Product Name	4-Phenylbutyric-D11 Acid
CAS No.	358730-86-6
Molecular Formula	C10D11HO2
Molecular Weight	179.26 g/mol (theoretical)
Synonyms	4-Phenyl[2,2,3,3,4,4,5,5,6,6,6-D11]butyric Acid; Benzenebutanoic-2,2,3,3,4,4,5,5,6,6,6-d11 Acid; 4-PBA-d11; Deuterated 4-Phenylbutyric Acid; Phenylbutyric Acid-d11; γ-Phenylbutyric Acid-d11; (4-Phenylbutyl-d11)-1-carboxylic Acid; 4-Phenylbutanoic-d11 Acid
EINECS	Contact for details

Quality Control

Our 4-Phenylbutyric-D11 Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR and mass spectrometry, to confirm isotopic purity and chemical identity. A detailed Certificate of Analysis (COA) is provided with each shipment, reporting key parameters such as chemical purity, isotopic enrichment, and solvent content to ensure it meets the stringent requirements for research and analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Chemical Purity	≥ 95% (by NMR)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.