Description

o-(2,3,4,5,6-Pentafluorobenzyl-Alpha,α-D2)-Hydroxylamine Hcl is a deuterated and fluorinated hydroxylamine derivative, serving as a specialized building block and analytical standard. This compound is critical for applications requiring high isotopic purity and structural specificity, such as advanced mass spectrometry and metabolic pathway studies. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, development, and bioanalytical method validation.

Application

• Stable Isotope Labeled Internal Standards for precise quantitative analysis in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS).
• Pharmaceutical Research & Development as a key synthetic intermediate for creating novel fluorinated and deuterated drug candidates.
• Metabolomics and Proteomics Studies to trace and quantify biochemical pathways and protein modifications.
• Chemical Derivatization Agent for enhancing the detection sensitivity and specificity of carbonyl-containing analytes in complex matrices.
• Academic Research in organic chemistry for studying reaction mechanisms involving hydroxylamine and fluorinated aromatic systems.
• Reference Material for calibrating analytical instruments and validating methods in regulatory environments (GLP/GMP).

Basic Information

Product Name	o-(2,3,4,5,6-Pentafluorobenzyl-Alpha,α-D2)-Hydroxylamine Hcl
CAS No.	358730-85-5
Molecular Formula	C7H2D2F5NO·HCl
Molecular Weight	251.60 g/mol
Synonyms	Hydroxylamine, O-[(2,3,4,5,6-pentafluorophenyl)methyl]-, hydrochloride, alpha,α-dideuterio-; O-(Pentafluorobenzyl)hydroxylamine-d2 hydrochloride; PFBHA-d2 HCl; 2,3,4,5,6-Pentafluorobenzyloxyamine-d2 hydrochloride; (2,3,4,5,6-Pentafluorobenzyl)hydroxylamine-d2 HCl; Deuterated PFBHA HCl; O-(Perfluorobenzyl)hydroxylamine-d2 hydrochloride
EINECS	Contact for details

Quality Control

Our o-(2,3,4,5,6-Pentafluorobenzyl-Alpha,α-D2)-Hydroxylamine Hcl is manufactured under strict quality systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chemical purity, isotopic enrichment (D-content), and impurity profile. We adhere to relevant standards for high-purity research chemicals, and custom synthesis and purification to meet specific client requirements are available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.