Description

2H-Indol-2-One,3-Fluoro-1,3-Dihydro-3-Methyl-,(+)-(9Ci) is a high-purity, chiral fluorinated indolinone derivative of significant interest in advanced organic synthesis. This compound serves as a critical pharmaceutical intermediate and a versatile building block for the development of novel bioactive molecules. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for creating new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis due to its fluorinated indolinone structure.
• Agrochemical Synthesis: Employed in the development of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and stability.
• Organic Synthesis Building Block: Utilized in asymmetric synthesis and cross-coupling reactions to construct complex heterocyclic compounds.
• Biochemical Probe Development: Acts as a precursor for fluorescent tags or enzyme inhibitors used in biochemical and cellular assays.

Basic Information

Product Name	2H-Indol-2-One,3-Fluoro-1,3-Dihydro-3-Methyl-,(+)-(9Ci)
CAS No.	358335-68-9
Molecular Formula	C9H8FNO
Molecular Weight	165.17 g/mol
Synonyms	(+)-3-Fluoro-3-methylindolin-2-one; (3R)-3-Fluoro-3-methyl-1,3-dihydro-2H-indol-2-one; 3-Fluoro-3-methyl-2-indolinone; 3-Fluoro-3-methyloxindole; (R)-3-Fluoro-3-methylindolin-2-one; 358335-68-9; (+)-3-Fluoro-3-methyl-2-oxindole
EINECS	Contact for details

Quality Control

We supply this fluorinated building block under a strict quality management system. Each batch is characterized and tested to ensure identity, purity, and chiral integrity, meeting the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing chiral purity (enantiomeric excess), chemical purity (by HPLC), and full spectroscopic data (NMR, MS, IR) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.