Description

(R)-(+)-n-Methyl-1-Phenylethylamine-D13 CAS NO 357407-86-4 is a high-purity, deuterium-labeled chiral amine, specifically the (R)-(+)-enantiomer of α-methylbenzylamine with a fully deuterated methyl group. This compound is a critical analytical standard and building block for research requiring isotopic labeling to study metabolic pathways, reaction mechanisms, or to serve as an internal standard in mass spectrometry. It is essential for scientists and process developers in pharmaceutical research, agrochemical development, and advanced material science who require precise isotopic purity and enantiomeric excess for accurate trace analysis and kinetic studies.

Application

• Internal Standard for Quantitative Mass Spectrometry (MS): Used in LC-MS and GC-MS analyses for the accurate quantification of non-labeled α-methylbenzylamine and related compounds in complex matrices.
• Metabolic and Pharmacokinetic Studies: Serves as a tracer in drug metabolism and disposition (DMPK) studies to elucidate metabolic pathways and bioavailability of chiral amine-containing pharmaceuticals.
• Mechanistic Reaction Studies: Employed in catalytic and synthetic chemistry to investigate reaction mechanisms, including asymmetric synthesis and hydrogenation/deuteration processes, via isotopic labeling.
• Chiral Resolution Agent Development: Acts as a high-purity, labeled precursor or resolving agent in the development and validation of chiral separation methods for HPLC and SFC.
• Deuterated Pharmaceutical Intermediate: A key building block for the synthesis of deuterated drug candidates, where the incorporation of deuterium can alter metabolic profiles and improve drug stability.
• NMR Spectroscopy Solvent & Reagent: Useful as a chiral shift reagent or in preparing deuterated samples for complex NMR spectroscopic analysis.

Basic Information

Item	Detail
Product Name	(R)-(+)-n-Methyl-1-Phenylethylamine-D13
CAS No.	357407-86-4
Molecular Formula	C9H2D13N
Molecular Weight	~143.3 g/mol
Synonyms	(R)-(+)-α-Methylbenzylamine-d13; (R)-1-Phenylethylamine-d13 (N-methyl-d3); (R)-(+)-1-Phenylethylamine-d13 (N-CD3); (R)-N-Methyl-1-phenylethan-1-amine-d13; (R)-N-Methyl-α-methylbenzylamine-d13; Deuterated (R)-(+)-N-Methylamphetamine; (R)-N-Methylamphetamine-d13; d13-(R)-N-Methyl-1-phenylethylamine
EINECS	Contact for details

Quality Control

Every batch of our (R)-(+)-n-Methyl-1-Phenylethylamine-D13 is produced and analyzed under strict quality management protocols. We guarantee high isotopic purity (D-enrichment) and enantiomeric excess (ee), which are critical for its application as a reference material. Identity, purity, and isotopic distribution are confirmed by advanced analytical techniques including NMR, MS, and chiral HPLC. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment to ensure traceability and compliance with your research or quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use to prevent evaporation and potential contamination. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 99 atom % D
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.