Description

n-Methoxy-n-Methylthiophene-3-Carboxamide CAS NO 357405-56-2 is a specialized heterocyclic building block and a Weinreb amide derivative. This compound is a critical intermediate in organic synthesis, prized for its ability to act as a stable acyl anion equivalent, enabling the controlled formation of ketones from organometallic reagents. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the construction of complex thiophene-containing molecules, which are prevalent in active pharmaceutical ingredients (APIs) and crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly those containing the thiophene pharmacophore for therapeutic areas like CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the thiophene ring contributes to biological activity.
• Material Science Research: Serves as a precursor for developing organic electronic materials, such as conductive polymers and organic semiconductors, due to the electron-rich nature of thiophene.
• Chemical Biology & Proteomics: Employed as a tool compound or linker in the synthesis of chemical probes for studying biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses (CROs/CMOs) producing bespoke compounds for client R&D programs.
• Academic Research: Fundamental reagent in university laboratories for methodological development in organic chemistry and heterocyclic chemistry studies.

Basic Information

Product Name	n-Methoxy-n-Methylthiophene-3-Carboxamide
CAS No.	357405-56-2
Molecular Formula	C8H11NO2S
Molecular Weight	185.24 g/mol
Synonyms	3-Thiophenecarboxamide, N-methoxy-N-methyl-; N-Methoxy-N-methyl-3-thiophenecarboxamide; N-Methoxy-N-methylthiophene-3-carboxamide; N,3-Dimethoxy-N-methyl-3-thiophenecarboxamide; 3-(N-Methoxy-N-methylcarbamoyl)thiophene; Thiophene-3-carboxylic acid N-methoxy-N-methylamide; Weinreb amide of 3-thiophenecarboxylic acid
EINECS	Contact for details

Quality Control

Our n-Methoxy-n-Methylthiophene-3-Carboxamide is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our commitment to quality ensures batch-to-batch consistency, which is critical for your research and process development success.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.