Description

Brivaracetam (Alfar, 4R)-Isomer is the pharmacologically active enantiomer of the antiepileptic drug Brivaracetam. This high-purity isomer is critical for pharmaceutical research and development, offering superior specificity for studying receptor binding and metabolic pathways. It is primarily required by pharmaceutical companies, research institutions, and CDMOs engaged in the development of advanced central nervous system (CNS) therapeutics and generic formulations.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Serves as the key chiral building block for the manufacture of Brivaracetam and related pharmaceutical compounds.
• Pharmacological Research: Used in preclinical and clinical studies to investigate the precise mechanism of action, efficacy, and safety profile of the (4R)-isomer.
• Analytical Reference Standard: Employed as a certified reference material (CRM) for method development, validation, and quality control testing in HPLC, GC, and LC-MS assays.
• Process Development & Optimization: Essential for scaling up enantioselective synthesis routes and improving yield and purity in manufacturing processes.
• Generic Drug Development: A critical component for companies developing bioequivalent versions of branded antiepileptic medications.

Basic Information

Product Name	Brivaracetam (Alfar, 4R)-Isomer
CAS No.	357337-00-9
Molecular Formula	C11H20N2O2
Molecular Weight	212.29 g/mol
Synonyms	(4R)-Brivaracetam; (4R)-2-Oxo-1-pyrrolidineacetamide, 4-[(2R)-2-bromobutyl]-; (R)-Brivaracetam; (R)-4-(2-Bromobutyl)-2-oxo-1-pyrrolidineacetamide; UCB 34714 (Isomer); Alfar Isomer of Brivaracetam; (4R)-4-[(2R)-2-Bromobutyl]-2-oxo-1-pyrrolidineacetamide; Seletracetam (Alfar isomer)
EINECS	Contact for details

Quality Control

Our Brivaracetam (Alfar, 4R)-Isomer is manufactured under strict quality systems. Each batch is tested to ensure compliance with high-purity standards suitable for pharmaceutical R&D. Comprehensive testing includes chiral purity, chemical assay, and identification of related substances. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Enantiomeric Excess)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.