Description

Brivaracetam (Alfar, 4S)-Isomer is a high-purity, stereochemically defined enantiomer of the antiepileptic drug brivaracetam. This specific isomer is critical for pharmaceutical research and development, particularly in the study of structure-activity relationships and the production of advanced active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in neuroscience research and the development of next-generation seizure medications.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for analytical method development, validation, and quality control testing of brivaracetam-based drug products.
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the synthesis and scale-up production of the final brivaracetam API, ensuring stereochemical purity.
• Neurological Research: A key tool compound for preclinical studies investigating the mechanisms of action, efficacy, and safety profiles of SV2A ligands.
• Process Chemistry & Optimization: Employed in route scouting and process development to improve the yield and purity of stereoselective syntheses.
• Regulatory Submissions: Provides essential data and materials for regulatory filings (e.g., with FDA, EMA) requiring characterization of specific isomers.
• Impurity Profiling: Used to identify, quantify, and qualify stereoisomeric impurities in brivaracetam batches.

Basic Information

Product Name	Brivaracetam (Alfar, 4S)-Isomer
CAS No.	357336-99-3
Molecular Formula	C11H20N2O2
Molecular Weight	212.29 g/mol
Synonyms	(4S)-4-Propyl-dihydro-2(3H)-furanone; (4S)-4-Propyl-2-pyrrolidinone; (4S)-4-n-Propyl-2-pyrrolidinone; (4S)-4-Propylpyrrolidin-2-one; UCB 34714 Isomer; Brivaracetam Enantiomer; Brivaracetam (4S)-Isomer; (Alfar)-Brivaracetam
EINECS	Contact for details

Quality Control

Our Brivaracetam (Alfar, 4S)-Isomer is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) that detail all specifications, ensuring compliance with ICH guidelines and customer-specific requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Long-term storage under inert atmosphere is recommended.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.