Description

(4S)-Brivaracetam CAS NO 357336-19-7 is a high-purity, single-enantiomer pharmaceutical intermediate and active pharmaceutical ingredient (API). This compound is the pharmacologically active (S)-enantiomer of brivaracetam, a racetam derivative with potent and selective binding affinity for synaptic vesicle protein 2A (SV2A). It is essential for the research, development, and commercial manufacturing of advanced antiepileptic drugs. This material is primarily targeted at pharmaceutical R&D laboratories, API manufacturers, and contract development and manufacturing organizations (CDMOs) focused on central nervous system (CNS) therapeutics.

Application

• Active Pharmaceutical Ingredient (API) for the synthesis of Brivaracetam, a next-generation antiepileptic drug.
• Pharmaceutical Intermediate in the enantioselective synthesis of SV2A ligand-based therapeutics.
• Reference Standard for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Preclinical and Clinical Research material for studying the pharmacology and efficacy of levetiracetam analogs.
• Process Chemistry Development for optimizing synthetic routes and scaling up production.
• Regulatory Filings supporting New Drug Applications (NDA) and Abbreviated New Drug Applications (ANDA).

Basic Information

Product Name	(4S)-Brivaracetam
CAS No.	357336-19-7
Molecular Formula	C11H20N2O2
Molecular Weight	212.29 g/mol
Synonyms	(2S)-2-[(4R)-2-Oxo-4-propylpyrrolidin-1-yl]butanamide; (S)-Brivaracetam; Brivaracetam Impurity F; UCB 34714; (4S)-2-Oxo-4-propyl-1-pyrrolidineacetamide; UNII-56I13V8FQO; BRV; (alphaS)-α-ethyl-2-oxo-4-propyl-1-pyrrolidineacetamide
EINECS	Contact for details

Quality Control

Our (4S)-Brivaracetam is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and enantiomeric excess. We provide full traceability and support regulatory requirements with comprehensive documentation. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available for every lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) in a desiccator after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Chiral HPLC)	≥ 99.0% (4S)-enantiomer
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.