Description

Carbamic Acid, [(1R)-2-Hydroxy-1-(Mercaptomethyl)Ethyl]-, 1,1-Dimethylethyl is a specialized chiral building block featuring both a protected carbamate and a free thiol functional group. This compound is critical for the synthesis of complex molecules where precise stereochemistry and orthogonal reactivity are required. It is primarily utilized by pharmaceutical and biotechnology R&D teams for the development of novel active pharmaceutical ingredients (APIs), particularly in the areas of protease inhibitors and targeted covalent inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, especially for targeted covalent drugs.
• Protease Inhibitor Synthesis: Used in constructing the core scaffold of inhibitors for various proteases due to its reactive thiol moiety.
• Peptidomimetics: Serves as a building block for creating non-peptide compounds that mimic the structure and function of peptides.
• Bioconjugation Chemistry: The free thiol group enables site-specific conjugation to proteins, antibodies, or other biomolecules for drug delivery systems.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes for studying enzyme function and mechanism.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or reagent in stereoselective chemical transformations.

Basic Information

Product Name	Carbamic Acid, [(1R)-2-Hydroxy-1-(Mercaptomethyl)Ethyl]-, 1,1-Dimethylethyl
CAS No.	357205-17-5
Molecular Formula	C8H17NO3S
Molecular Weight	207.29 g/mol
Synonyms	(R)-tert-Butyl (1-mercapto-2-hydroxypropan-3-yl)carbamate; (R)-3-((tert-Butoxycarbonyl)amino)-2-hydroxypropane-1-thiol; (1R)-1-(Mercaptomethyl)-2-hydroxyethylcarbamic Acid tert-Butyl Ester; Boc-Cys-ol; tert-Butyl N-[(2R)-1-mercapto-2-hydroxy-3-propyl]carbamate; (R)-2-Hydroxy-3-mercaptopropylcarbamic Acid tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our production of Carbamic Acid, [(1R)-2-Hydroxy-1-(Mercaptomethyl)Ethyl]-, 1,1-Dimethylethyl adheres to stringent quality management systems to ensure batch-to-batch consistency and high chemical purity. All material is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation of the thiol group and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area separate from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.