Description

Toceranib is a small molecule tyrosine kinase inhibitor with potent activity against specific receptor targets. This compound is critical for research and development in the pharmaceutical and veterinary medicine sectors, particularly in oncology. It is primarily utilized by researchers and manufacturers developing targeted therapies for specific cancers in companion animals and as a reference standard in biochemical studies.

Application

• Veterinary Oncology Drug Development: As the active pharmaceutical ingredient (API) in the development and manufacture of targeted cancer treatments for dogs, specifically for mast cell tumors.
• Biochemical Research: Used as a selective inhibitor in laboratory studies to investigate signal transduction pathways involving specific tyrosine kinases like PDGFR and Kit.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis (HPLC, LC-MS).
• Preclinical Studies: Employed in in vitro and in vivo models to study the efficacy and mechanism of action of kinase inhibition.
• Pharmaceutical Intermediates: Can be used as a key intermediate or starting material in the synthesis of novel kinase inhibitor analogs.

Basic Information

Product Name	Toceranib
CAS No.	356068-94-5
Molecular Formula	C₂₂H₂₇FN₄O₃
Molecular Weight	414.47 g/mol
Synonyms	Toceranib phosphate; SU11654; Palladia (trade name); 3-[(4-Methyl-1-piperazinyl)methyl]-N-[4-(trifluoromethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-5-amine; 5-Amino-3-[(4-methyl-1-piperazinyl)methyl]-N-[4-(trifluoromethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridine; SU-11654; Toceranib (free base)
EINECS	Contact for details

Quality Control

Our Toceranib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting specifications suitable for research and development purposes. A Certificate of Analysis (COA) detailing results for assay, impurities (HPLC), residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.