Description

1-(8-Chloro-5-Isoquinolinesulfonyl)Piperazine, Dihydrochloride is a high-purity, synthetic organic compound primarily utilized as a key intermediate in advanced pharmaceutical research and development. This compound matters for its role in the synthesis of biologically active molecules, particularly in the exploration of novel enzyme inhibitors and receptor modulators. It is essential for research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality building blocks for drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of potential therapeutic agents, particularly kinase inhibitors.
• Biochemical Research: Used as a tool compound in enzymatic assays and for studying signal transduction pathways.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies in drug discovery projects.
• Reference Standard: Employed as an analytical standard for quality control and method development in API manufacturing.
• Chemical Biology Probes: Utilized in the development of molecular probes to investigate protein function and cellular processes.

Basic Information

Product Name	1-(8-Chloro-5-Isoquinolinesulfonyl)Piperazine, Dihydrochloride
CAS No.	355115-40-1
Molecular Formula	C₁₃H₁₅Cl₂N₃O₂S
Molecular Weight	364.25 g/mol
Synonyms	8-Chloro-5-(piperazine-1-sulfonyl)isoquinoline dihydrochloride; 1-(8-Chloro-5-isoquinolinesulfonyl)piperazine hydrochloride (1:2); Piperazine, 1-[(8-chloro-5-isoquinolinyl)sulfonyl]-, dihydrochloride; 355115-40-1; 8-Chloro-5-(piperazine-1-sulfonyl)isoquinoline 2HCl; 1-(8-Chloro-5-isoquinolinesulfonyl)piperazine 2HCl; 1-(8-Chloro-5-isoquinolinesulfonyl)piperazine HCl
EINECS	Contact for details

Quality Control

Our 1-(8-Chloro-5-Isoquinolinesulfonyl)Piperazine, Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere when not in use to maintain product integrity and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.